Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice.
Identifieur interne : 000134 ( Main/Exploration ); précédent : 000133; suivant : 000135Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice.
Auteurs : Muhammad Ijaz Ahmad [République populaire de Chine] ; Xiaoyou Zou [République populaire de Chine] ; Muhammad Umair Ijaz [République populaire de Chine] ; Muzahir Hussain [République populaire de Chine] ; Congcong Liu [République populaire de Chine] ; Xinglian Xu [République populaire de Chine] ; Guanghong Zhou [République populaire de Chine] ; Chunbao Li [République populaire de Chine]Source :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Cholestérol (sang), Cytokines (métabolisme), Facteur-2 apparenté à NF-E2 (génétique), Facteur-2 apparenté à NF-E2 (métabolisme), Femelle (MeSH), Foie (métabolisme), Glutarédoxines (déficit), Glutarédoxines (génétique), Humains (MeSH), Inflammation (génétique), Inflammation (immunologie), Inflammation (microbiologie), Inflammation (métabolisme), Lipogenèse (MeSH), Microbiome gastro-intestinal (MeSH), Mâle (MeSH), Produits carnés (effets indésirables), Protéine-1 de type kelch associée à ECH (génétique), Protéine-1 de type kelch associée à ECH (métabolisme), Souris (MeSH), Souris de lignée C57BL (MeSH), Souris knockout (MeSH), Transduction du signal (MeSH), Triglycéride (sang), Viande rouge (MeSH).
- MESH :
- déficit : Glutarédoxines.
- effets indésirables : Produits carnés.
- génétique : Facteur-2 apparenté à NF-E2, Glutarédoxines, Inflammation, Protéine-1 de type kelch associée à ECH.
- immunologie : Inflammation.
- microbiologie : Inflammation.
- métabolisme : Cytokines, Facteur-2 apparenté à NF-E2, Foie, Inflammation, Protéine-1 de type kelch associée à ECH.
- sang : Cholestérol, Triglycéride.
- Animaux, Femelle, Humains, Lipogenèse, Microbiome gastro-intestinal, Mâle, Souris, Souris de lignée C57BL, Souris knockout, Transduction du signal, Viande rouge.
English descriptors
- KwdEn :
- Animals (MeSH), Cholesterol (blood), Cytokines (metabolism), Female (MeSH), Gastrointestinal Microbiome (MeSH), Glutaredoxins (deficiency), Glutaredoxins (genetics), Humans (MeSH), Inflammation (genetics), Inflammation (immunology), Inflammation (metabolism), Inflammation (microbiology), Kelch-Like ECH-Associated Protein 1 (genetics), Kelch-Like ECH-Associated Protein 1 (metabolism), Lipogenesis (MeSH), Liver (metabolism), Male (MeSH), Meat Products (adverse effects), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), NF-E2-Related Factor 2 (genetics), NF-E2-Related Factor 2 (metabolism), Red Meat (MeSH), Signal Transduction (MeSH), Triglycerides (blood).
- MESH :
- chemical , blood : Cholesterol, Triglycerides.
- chemical , deficiency : Glutaredoxins.
- chemical , genetics : Glutaredoxins, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2.
- chemical , metabolism : Cytokines, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2.
- adverse effects : Meat Products.
- genetics : Inflammation.
- immunology : Inflammation.
- metabolism : Inflammation, Liver.
- microbiology : Inflammation.
- Animals, Female, Gastrointestinal Microbiome, Humans, Lipogenesis, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Red Meat, Signal Transduction.
Abstract
Oxidative stress may play a critical role in the progression of liver disorders. Increasing interest has been given to the associations among diet, oxidative stress, gut-liver axis, and nonalcoholic fatty liver disease. Here, we investigated the effects of processed meat proteins on biomarkers of lipid homeostasis, hepatic metabolism, antioxidant functions, and gut microbiota composition in glutaredoxin1 deficient (Glrx1-/-) mice. The wild-type (WT) and Glrx1-/- mice were fed a soy protein diet (SPD), a dry-cured pork protein diet (DPD), a braised pork protein diet (BPD), and a cooked pork protein diet (CPD) at a dose of 20% of protein for 3 months. Serum and hepatic total cholesterol, serum endotoxin, hepatic liver droplet %, and antioxidant capacity were significantly increased in the CPD fed WT mice. In addition, CPD fed Glrx1-/- mice significantly increased total cholesterol, triacylglycerol, and pro-inflammatory cytokines which are accompanied by higher steatosis scores, intrahepatic lipid accumulation, and altered gene expression associated with lipid metabolism. Furthermore, hepatic gene expression of Nrf2/keap1 signaling pathway and its downstream signaling targets were determined using RT-qPCR. Glrx1 deficiency increased Nrf2 activity and expression of its target genes (GPx, catalase, SOD1, G6pd, and Bbc3), which was exacerbated by intake of CPD. Metagenomic analyses revealed that Glrx1-/- mice fed meat protein diets had higher abundances of Mucispirillum, Oscillibacter, and Mollicutes but lower abundances of Bacteroidales S24-7 group_norank, Blautia, and Anaerotruncus than their wild-type counterparts. In summary, Glrx1 deficiency induced an increase in serum biomarkers for lipid homeostasis, gut microbiota imbalance, and upregulation of Nrf2/Keap1 and antioxidant defense genes, which was aggravated by cooked meat protein diet.
DOI: 10.1021/acs.jafc.9b03136
PubMed: 31345023
Affiliations:
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</wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Liu, Congcong" sort="Liu, Congcong" uniqKey="Liu C" first="Congcong" last="Liu">Congcong Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xinglian" sort="Xu, Xinglian" uniqKey="Xu X" first="Xinglian" last="Xu">Xinglian Xu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Guanghong" sort="Zhou, Guanghong" uniqKey="Zhou G" first="Guanghong" last="Zhou">Guanghong Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Li, Chunbao" sort="Li, Chunbao" uniqKey="Li C" first="Chunbao" last="Li">Chunbao Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31345023</idno><idno type="pmid">31345023</idno><idno type="doi">10.1021/acs.jafc.9b03136</idno><idno type="wicri:Area/Main/Corpus">000125</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000125</idno><idno type="wicri:Area/Main/Curation">000125</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000125</idno><idno type="wicri:Area/Main/Exploration">000125</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice.</title><author><name sortKey="Ahmad, Muhammad Ijaz" sort="Ahmad, Muhammad Ijaz" uniqKey="Ahmad M" first="Muhammad Ijaz" last="Ahmad">Muhammad Ijaz Ahmad</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Zou, Xiaoyou" sort="Zou, Xiaoyou" uniqKey="Zou X" first="Xiaoyou" last="Zou">Xiaoyou Zou</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Ijaz, Muhammad Umair" sort="Ijaz, Muhammad Umair" uniqKey="Ijaz M" first="Muhammad Umair" last="Ijaz">Muhammad Umair Ijaz</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Hussain, Muzahir" sort="Hussain, Muzahir" uniqKey="Hussain M" first="Muzahir" last="Hussain">Muzahir Hussain</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Liu, Congcong" sort="Liu, Congcong" uniqKey="Liu C" first="Congcong" last="Liu">Congcong Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xinglian" sort="Xu, Xinglian" uniqKey="Xu X" first="Xinglian" last="Xu">Xinglian Xu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Guanghong" sort="Zhou, Guanghong" uniqKey="Zhou G" first="Guanghong" last="Zhou">Guanghong Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author><author><name sortKey="Li, Chunbao" sort="Li, Chunbao" uniqKey="Li C" first="Chunbao" last="Li">Chunbao Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 </wicri:regionArea><wicri:noRegion>210095 </wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Cholesterol (blood)</term><term>Cytokines (metabolism)</term><term>Female (MeSH)</term><term>Gastrointestinal Microbiome (MeSH)</term><term>Glutaredoxins (deficiency)</term><term>Glutaredoxins (genetics)</term><term>Humans (MeSH)</term><term>Inflammation (genetics)</term><term>Inflammation (immunology)</term><term>Inflammation (metabolism)</term><term>Inflammation (microbiology)</term><term>Kelch-Like ECH-Associated Protein 1 (genetics)</term><term>Kelch-Like ECH-Associated Protein 1 (metabolism)</term><term>Lipogenesis (MeSH)</term><term>Liver (metabolism)</term><term>Male (MeSH)</term><term>Meat Products (adverse effects)</term><term>Mice (MeSH)</term><term>Mice, Inbred C57BL (MeSH)</term><term>Mice, Knockout (MeSH)</term><term>NF-E2-Related Factor 2 (genetics)</term><term>NF-E2-Related Factor 2 (metabolism)</term><term>Red Meat (MeSH)</term><term>Signal Transduction (MeSH)</term><term>Triglycerides (blood)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Cholestérol (sang)</term><term>Cytokines (métabolisme)</term><term>Facteur-2 apparenté à NF-E2 (génétique)</term><term>Facteur-2 apparenté à NF-E2 (métabolisme)</term><term>Femelle (MeSH)</term><term>Foie (métabolisme)</term><term>Glutarédoxines (déficit)</term><term>Glutarédoxines (génétique)</term><term>Humains (MeSH)</term><term>Inflammation (génétique)</term><term>Inflammation (immunologie)</term><term>Inflammation (microbiologie)</term><term>Inflammation (métabolisme)</term><term>Lipogenèse (MeSH)</term><term>Microbiome gastro-intestinal (MeSH)</term><term>Mâle (MeSH)</term><term>Produits carnés (effets indésirables)</term><term>Protéine-1 de type kelch associée à ECH (génétique)</term><term>Protéine-1 de type kelch associée à ECH (métabolisme)</term><term>Souris (MeSH)</term><term>Souris de lignée C57BL (MeSH)</term><term>Souris knockout (MeSH)</term><term>Transduction du signal (MeSH)</term><term>Triglycéride (sang)</term><term>Viande rouge (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Glutaredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutaredoxins</term><term>Kelch-Like ECH-Associated Protein 1</term><term>NF-E2-Related Factor 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Kelch-Like ECH-Associated Protein 1</term><term>NF-E2-Related Factor 2</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Meat Products</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Glutarédoxines</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Produits carnés</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur-2 apparenté à NF-E2</term><term>Glutarédoxines</term><term>Inflammation</term><term>Protéine-1 de type kelch associée à ECH</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Facteur-2 apparenté à NF-E2</term><term>Foie</term><term>Inflammation</term><term>Protéine-1 de type kelch associée à ECH</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cholestérol</term><term>Triglycéride</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Gastrointestinal Microbiome</term><term>Humans</term><term>Lipogenesis</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Red Meat</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Lipogenèse</term><term>Microbiome gastro-intestinal</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Transduction du signal</term><term>Viande rouge</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Oxidative stress may play a critical role in the progression of liver disorders. Increasing interest has been given to the associations among diet, oxidative stress, gut-liver axis, and nonalcoholic fatty liver disease. Here, we investigated the effects of processed meat proteins on biomarkers of lipid homeostasis, hepatic metabolism, antioxidant functions, and gut microbiota composition in glutaredoxin1 deficient (Glrx1<sup>-/-</sup>) mice. The wild-type (WT) and Glrx1<sup>-/-</sup> mice were fed a soy protein diet (SPD), a dry-cured pork protein diet (DPD), a braised pork protein diet (BPD), and a cooked pork protein diet (CPD) at a dose of 20% of protein for 3 months. Serum and hepatic total cholesterol, serum endotoxin, hepatic liver droplet %, and antioxidant capacity were significantly increased in the CPD fed WT mice. In addition, CPD fed Glrx1<sup>-/-</sup> mice significantly increased total cholesterol, triacylglycerol, and pro-inflammatory cytokines which are accompanied by higher steatosis scores, intrahepatic lipid accumulation, and altered gene expression associated with lipid metabolism. Furthermore, hepatic gene expression of Nrf2/keap1 signaling pathway and its downstream signaling targets were determined using RT-qPCR. Glrx1 deficiency increased Nrf2 activity and expression of its target genes (GPx, catalase, SOD1, G6pd, and Bbc3), which was exacerbated by intake of CPD. Metagenomic analyses revealed that Glrx1<sup>-/-</sup> mice fed meat protein diets had higher abundances of <i>Mucispirillum</i>, <i>Oscillibacter</i>, and <i>Mollicutes</i> but lower abundances of <i>Bacteroidales S24-7 group_norank</i>, <i>Blautia</i>, and <i>Anaerotruncus</i> than their wild-type counterparts. In summary, Glrx1 deficiency induced an increase in serum biomarkers for lipid homeostasis, gut microbiota imbalance, and upregulation of Nrf2/Keap1 and antioxidant defense genes, which was aggravated by cooked meat protein diet.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31345023</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>32</Issue><PubDate><Year>2019</Year><Month>Aug</Month><Day>14</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J Agric Food Chem</ISOAbbreviation></Journal><ArticleTitle>Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice.</ArticleTitle><Pagination><MedlinePgn>8794-8809</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acs.jafc.9b03136</ELocationID><Abstract><AbstractText>Oxidative stress may play a critical role in the progression of liver disorders. Increasing interest has been given to the associations among diet, oxidative stress, gut-liver axis, and nonalcoholic fatty liver disease. Here, we investigated the effects of processed meat proteins on biomarkers of lipid homeostasis, hepatic metabolism, antioxidant functions, and gut microbiota composition in glutaredoxin1 deficient (Glrx1<sup>-/-</sup>) mice. The wild-type (WT) and Glrx1<sup>-/-</sup> mice were fed a soy protein diet (SPD), a dry-cured pork protein diet (DPD), a braised pork protein diet (BPD), and a cooked pork protein diet (CPD) at a dose of 20% of protein for 3 months. Serum and hepatic total cholesterol, serum endotoxin, hepatic liver droplet %, and antioxidant capacity were significantly increased in the CPD fed WT mice. In addition, CPD fed Glrx1<sup>-/-</sup> mice significantly increased total cholesterol, triacylglycerol, and pro-inflammatory cytokines which are accompanied by higher steatosis scores, intrahepatic lipid accumulation, and altered gene expression associated with lipid metabolism. Furthermore, hepatic gene expression of Nrf2/keap1 signaling pathway and its downstream signaling targets were determined using RT-qPCR. Glrx1 deficiency increased Nrf2 activity and expression of its target genes (GPx, catalase, SOD1, G6pd, and Bbc3), which was exacerbated by intake of CPD. Metagenomic analyses revealed that Glrx1<sup>-/-</sup> mice fed meat protein diets had higher abundances of <i>Mucispirillum</i>, <i>Oscillibacter</i>, and <i>Mollicutes</i> but lower abundances of <i>Bacteroidales S24-7 group_norank</i>, <i>Blautia</i>, and <i>Anaerotruncus</i> than their wild-type counterparts. In summary, Glrx1 deficiency induced an increase in serum biomarkers for lipid homeostasis, gut microbiota imbalance, and upregulation of Nrf2/Keap1 and antioxidant defense genes, which was aggravated by cooked meat protein diet.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahmad</LastName><ForeName>Muhammad Ijaz</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Xiaoyou</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ijaz</LastName><ForeName>Muhammad Umair</ForeName><Initials>MU</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussain</LastName><ForeName>Muzahir</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Congcong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Xinglian</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Guanghong</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8960-2141</Identifier><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chunbao</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0708-891X</Identifier><AffiliationInfo><Affiliation>Key Laboratory of Meat Processing and Quality Control, MOE; Key Laboratory of Meat Processing, MARA; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control; College of Food Science and Technology , Nanjing Agricultural University , Nanjing , 210095 , China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>08</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C516006">Glrx protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000072019">Kelch-Like ECH-Associated Protein 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051267">NF-E2-Related Factor 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014280">Triglycerides</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069196" MajorTopicYN="N">Gastrointestinal Microbiome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000072019" MajorTopicYN="N">Kelch-Like ECH-Associated Protein 1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050155" MajorTopicYN="Y">Lipogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008461" MajorTopicYN="N">Meat Products</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051267" MajorTopicYN="N">NF-E2-Related Factor 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069466" MajorTopicYN="N">Red Meat</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014280" MajorTopicYN="N">Triglycerides</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Glrx1 deficiency</Keyword><Keyword MajorTopicYN="N">fecal microbiota</Keyword><Keyword MajorTopicYN="N">gut-liver axis</Keyword><Keyword MajorTopicYN="N">meat proteins</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31345023</ArticleId><ArticleId IdType="doi">10.1021/acs.jafc.9b03136</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ahmad, Muhammad Ijaz" sort="Ahmad, Muhammad Ijaz" uniqKey="Ahmad M" first="Muhammad Ijaz" last="Ahmad">Muhammad Ijaz Ahmad</name></noRegion><name sortKey="Hussain, Muzahir" sort="Hussain, Muzahir" uniqKey="Hussain M" first="Muzahir" last="Hussain">Muzahir Hussain</name><name sortKey="Ijaz, Muhammad Umair" sort="Ijaz, Muhammad Umair" uniqKey="Ijaz M" first="Muhammad Umair" last="Ijaz">Muhammad Umair Ijaz</name><name sortKey="Li, Chunbao" sort="Li, Chunbao" uniqKey="Li C" first="Chunbao" last="Li">Chunbao Li</name><name sortKey="Liu, Congcong" sort="Liu, Congcong" uniqKey="Liu C" first="Congcong" last="Liu">Congcong Liu</name><name sortKey="Xu, Xinglian" sort="Xu, Xinglian" uniqKey="Xu X" first="Xinglian" last="Xu">Xinglian Xu</name><name sortKey="Zhou, Guanghong" sort="Zhou, Guanghong" uniqKey="Zhou G" first="Guanghong" last="Zhou">Guanghong Zhou</name><name sortKey="Zou, Xiaoyou" sort="Zou, Xiaoyou" uniqKey="Zou X" first="Xiaoyou" last="Zou">Xiaoyou Zou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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